The Phenol Red Clearance in Normal Man.

The Control of Renal Blood Flow and Glomerular Filtration in Normal Man.

This report is concerned with the effective renal blood flow and rate of glomerular filtration in normal man, as determined by the diodrast and inulin clearances (26) during diuresis and during the action of phlorizin, adrenin, caffeine, nitrite, and typhoid vaccine. The observations not only throw light on the action of these agents, but also afford information concerning the physiological con...

Pharmacokinetics of phenol red in rat models of liver damage prepared by liver targeting of carbon tetrachloride.

Animal models prepared by treatment with carbon tetrachloride (CCl(4)) have been used to examine drug disposition in hepatic disorder. However, previous studies demonstrated that systemic administration of CCl(4) impaired not only hepatic but also renal function. We recently reported that application of CCl(4) to the rat liver surface produced hepatic damage without impairing renal function. In...

Renal Function as Affected by Experimental Unilateral Kidney Lesions

1. A method is described for the production of a nephrosis in one kidney of an experimental animal. The normal kidney in the same animal is available for a control. 2. The nephrosis produced by the injection of 7.5 per cent sodium tartrate is limited to the proximal convoluted tubule. There is no histological evidence of glomerular damage. 3. This damage results in a disturbance of water and ch...

The Filtration Rate, Effective Renal Blood Flow, Tubular Excretory Mass and Phenol Red Clearance in Normal Pregnancy.

Disparity between phenol red and diodrast clearances in the dog.

The clearance of radioiodinated Diodrast and that of phenol red were compared in anesthetized dogs in an attempt to determine the reason why the former is roughly twice the latter, even though the two substances are secreted by the same mechanism. The infusion of sodium acetate increases both clearances but does not alter the ratio of the two. Hence availability of substrate is not likely to be...